Anti-PTPH1抗体-抗体-抗体-生物在线
Anti-PTPH1抗体

Anti-PTPH1抗体

商家询价

产品名称: Anti-PTPH1抗体

英文名称: PTPH1

产品编号: YB--9187R

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-PTPH1抗体

产品编号 YB-9187R
英文名称 PTPH1
中文名称 蛋白酪氨酸磷酸酶H1抗体
别    名 cytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase H1; protein tyrosine phosphatase non-receptor type 3; Protein-tyrosine phosphatase H1; PTN3_HUMAN; PTP H1; PTP-H1; PTPH1; PTPN3; Tyrosine-protein phosphatase non-receptor type 3.  
规格价格 100ul/1580元 购买    200ul/2480元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域 肿瘤  细胞生物  免疫学  信号转导  激酶和磷酸酶  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 104kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPH1/PTPN3:11-110/913 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. PTP-H1 shares homology with the cytoskeletal-associated proteins band 4.1, ezrin, and talin and has been shown to contain a PDZ and band 4.1 domain. These domains are responsible for targeting proteins to the cytoskeleton-membrane interface, as well as mediating protein-protein interactions, recognizing C-terminal valine residues and binding to other PDZ domains. Overexpression of PTP-H1 may reverse transformation induced by oncogenic protein-tyrosine kinases, such as the members of the src family.

Function:
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Subcellular Location:
Cell membrane. Cytoplasm. cytoskeleton.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Contains 1 FERM domain. 
Contains 1 PDZ (DHR) domain. 
Contains 1 tyrosine-protein phosphatase domain. 

SWISS:
P26045

Gene ID:
5774

Database links:

Entrez Gene: 5774 Human

Entrez Gene: 545622 Mouse

Omim: 176877 Human

SwissProt: P26045 Human

SwissProt: A2ALK8 Mouse

Unigene: 436429 Human

Unigene: 246552 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications