Anti-NR2C2/FITC Conjugated抗体-抗体-抗体-生物在线

Anti-NR2C2/FITC Conjugated抗体

商家询价

产品名称： Anti-NR2C2/FITC Conjugated抗体

英文名称： Anti-NR2C2/FITC

产品编号： YB--4636R-FITC

产品价格： null

产品产地：中国/美国

品牌商标： Ybscience

更新时间： 2023-08-17T10:29:50

使用范围：科研使用

上海钰博生物科技有限公司

联系人 : 陈环环
地址 : 上海市沪闵路6088号龙之梦大厦8楼806室
邮编 : 200612
所在区域 : 上海
电话 : 183****2235
传真 : 021-60514606
邮箱 : shybio@126.com

进入展台

产品详情

Anti-NR2C2/FITC Conjugated抗体

产品编号	YB-4636R-FITC
英文名称	Anti-NR2C2/FITC
中文名称	FITC标记的孤儿核受体TAK1抗体
别名	hTAK1; NR2C2; NR2C2_HUMAN; Nuclear hormone receptor TR4; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; TAK1; Testicular nuclear receptor 4; Testicular receptor 4; TR2R1; TR4; TR4 nuclear hormone receptor.
规格价格	100ul/2980元购买大包装/询价
说明书	100ul
研究领域	细胞生物信号转导表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
产品应用	IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	65-67kDa
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human NR2C2/TAK1
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. Subunit: Homodimer; can bind DNA as homodimer. Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF; the interaction preferentially occurs on the non-phosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity. Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity. Interacts with NLRP10. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF. Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 395253 Chicken Entrez Gene: 7182 Human Entrez Gene: 22026 Mouse Entrez Gene: 50659 Rat Omim: 601426 Human SwissProt: P49116 Human SwissProt: P49117 Mouse SwissProt: P55094 Rat Unigene: 555973 Human Unigene: 442385 Mouse Unigene: 476867 Mouse Unigene: 87062 Mouse Unigene: 10485 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.