Anti-SCN10A/Nav1.8/FITC Conjugated抗体
产品名称： Anti-SCN10A/Nav1.8/FITC Conjugated抗体
英文名称： Anti-SCN10A/Nav1.8/FITC
产品编号： YB--6685R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
- 联系人 : 陈环环
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- 邮编 : 200612
- 所在区域 : 上海
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- 传真 : 021-60514606
- 邮箱 : shybio@126.com
Anti-SCN10A/Nav1.8/FITC Conjugated抗体
| 品编号 | YB-6685R-FITC |
| 英文名称 | Anti-SCN10A/Nav1.8/FITC |
| 中文名称 | FITC标记的钠通道蛋白10α抗体 |
| 别 名 | mPN3; Peripheral nerve sodium channel 3; Pn3 (gene name)v PN3; Scn10a; Sensory neuron sodium channel; Sns (gene name); SNS; sodium channel protein type 10 subunit alpha; Sodium channel protein type X alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.8; NAV1.8. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 通道蛋白 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 215kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SCN10A/NAV1.8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Nav1.8 protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Nav1.8 forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Nav1.8 plays a role in neuropathic pain mechanisms. Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Subunit: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L. Subcellular Location: Membrane; Multi-pass membrane protein. Note=It can be translocated to the extracellular membrane through association with S100A10. Tissue Specificity: Expressed in the dorsal root ganglia and sciatic nerve. Post-translational modifications: Ubiquitinated by NEDD4L; which promotes its endocytosis. Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Contains 1 IQ domain. Database links: Entrez Gene: 6336 Human Entrez Gene: 20264 Mouse Entrez Gene: 29571 Rat Omim: 604427 Human SwissProt: Q9Y5Y9 Human SwissProt: P70276 Mouse SwissProt: Q6QIY3 Mouse SwissProt: Q62968 Rat Unigene: 250443 Human Unigene: 10246 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |