Anti-ASPP1/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-ASPP1/FITC Conjugated抗体

Anti-ASPP1/FITC Conjugated抗体

商家询价

产品名称: Anti-ASPP1/FITC Conjugated抗体

英文名称: Anti-ASPP1/FITC

产品编号: YB--1282R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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  • 邮编 : 200612
  • 所在区域 : 上海
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  • 邮箱 : shybio@126.com

 Anti-ASPP1/FITC Conjugated抗体

产品编号 YB-1282R-FITC
英文名称 Anti-ASPP1/FITC
中文名称 FITC标记的p53凋亡刺激蛋白1抗体
别    名 p53BP2 like; p85; PPP1R13B; apoptosis stimulating protein of P53 1; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ASPP1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
iASPP (inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor (RAI), NFKap B-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L) is the third member of the ASPP family of proteins. Unlike ASPP1 and ASPP2, which interact with p53 and enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFKap B (RelA),3 interacts with NFKap B in vivo, and acts as an efficient inhibitor of HIV-1 gene expression in which both NFKap b and Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, and gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia. Alternate Names: apoptosis stimulating protein of P53 1; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51.

Function:
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.

Subunit:
Interacts with TP53.

Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear.

Tissue Specificity:
Reduced expression in breast carcinomas expressing a wild-type TP53 protein.

Similarity:
Belongs to the ASPP family. 
Contains 2 ANK repeats. 
Contains 1 SH3 domain.

Database links:

Entrez Gene: 23368 Human

Entrez Gene: 21981 Mouse

Omim: 606455 Human

SwissProt: Q96KQ4 Human

SwissProt: Q62415 Mouse

Unigene: 709297 Human

Unigene: 313076 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

p53凋亡刺激蛋白(apoptosis stimulating protein of p53,ASPP)家族是近年来发现的一个新蛋白家族,它包括3个成员:ASPP1、ASPP2和其中ASPP1和ASPP2能够与p53蛋白结合增强该蛋白的促进细胞凋亡的功能,发挥抑制肿瘤的作用;而iASPP与ASPP1和ASPP2的功能截然相反,它能够和ASPP1或ASPP2竞争性地与p53结合,抑制ASPP1或ASPP2的促进凋亡作用,具有癌基因的功能。三者的结构相似,但功能却完全不同,通过研究三者的关系、促进肿瘤细胞内ASPP1或ASPP2的高表达以及抑制iASPP的表达有可能促进肿瘤细胞的凋亡,成为肿瘤治疗的新靶点