Anti-PLEKHO1/FITC Conjugated抗体
产品名称： Anti-PLEKHO1/FITC Conjugated抗体
英文名称： Anti-PLEKHO1/FITC
产品编号： YB--1330R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
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Anti-PLEKHO1/FITC Conjugated抗体
| 产品编号 | YB-1330R-FITC |
| 英文名称 | Anti-PLEKHO1/FITC |
| 中文名称 | FITC标记的酪蛋白激酶2相互作用蛋白1抗体 |
| 别 名 | PLEKHO1; C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting protein 1; CK2 interacting protein 1 HQ0024c protein; CK2-interacting protein 1; CKIP-1; CKIP 1; CKIP1; JBP; OC120; Osteoclast maturation associated gene 120 protein; Pleckstrin homology domain containing family O member 1; PKHO1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CKIP-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2(CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. Function: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. Subunit: Heterodimer or homodimer. Subcellular Location: Cell membrane. Nucleus. Cytoplasm. Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells. Tissue Specificity: Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cancer cell lines such as MOLT-4, HEK293 and Jurkat cells. Post-translational modifications: C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage. Similarity: Contains 1 PH domain. Database links: Entrez Gene: 51177 Human Entrez Gene: 67220 Mouse Entrez Gene: 310674 Rat Omim: 608335 Human SwissProt: Q53GL0 Human SwissProt: Q9JIY0 Mouse SwissProt: Q5BJM5 Rat Unigene: 438824 Human Unigene: 458147 Mouse Unigene: 21037 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 酪蛋白激酶2相互作用蛋白1是近年来发现的一种重要分子，它通过与其他分子的相互作用在许多细胞行为中都发挥着重要的作用。 CKIP-1还具有促进细胞凋亡的作用。CKIP-1可以与caspase-3形成正反馈环，增强肿瘤细胞的凋亡 |