Anti-SSB/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-SSB/FITC Conjugated抗体

Anti-SSB/FITC Conjugated抗体

商家询价

产品名称: Anti-SSB/FITC Conjugated抗体

英文名称: Anti-SSB/FITC

产品编号: YB--0276R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-SSB/FITC Conjugated抗体

产品编号 YB-0276R-FITC
英文名称 Anti-SSB/FITC
中文名称 FITC标记的干燥症SSB/La抗体
别    名 SSB; Lupus La protein homolog; La ribonucleoprotein; La autoantigen homolog; Sjogren syndrome type B antigen; LA_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SSB
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Lupus La protein (Sjogren syndrome type B antigen) (SS-B) (La ribonucleoprotein) (La autoantigen) plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5S, 7S, and 7-2 RNAs. The phosphorylation sites are at the C-terminal part of the protein. Sera from patients with systemic lupus erythematosus(SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.

Function:
Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

Subunit:
Interacts with DDX15. May interact with RUFY1.

Subcellular Location:
Nucleus (Probable). 

Post-translational modifications:
Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. 
The N-terminus is blocked. 

Similarity:
Contains 1 HTH La-type RNA-binding domain. 
Contains 1 RRM (RNA recognition motif) domain. 

Database links:

Entrez Gene: 20823 Mouse

Entrez Gene: 6741 Human

Entrez Gene: 20823 Mouse

Entrez Gene: 81783 Rat

GenBank: NP_003133.1 Human

Omim: 109090 Human

SwissProt: P05455 Human

SwissProt: P32067 Mouse

SwissProt: P38656 Rat

Unigene: 632535 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

同SSA,广泛应用于各种自身免疫性疾病检测