Anti-Nogo R/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Nogo R/FITC Conjugated抗体

Anti-Nogo R/FITC Conjugated抗体

商家询价

产品名称: Anti-Nogo R/FITC Conjugated抗体

英文名称: Anti-Nogo R/FITC

产品编号: YB--0129R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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  • 所在区域 : 上海
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  • 邮箱 : shybio@126.com

 Anti-Nogo R/FITC Conjugated抗体

产品编号 YB-0129R-FITC
英文名称 Anti-Nogo R/FITC
中文名称 FITC标记的轴索过度生长抑制因子受体/Nogo受体抗体
别    名 NgR; Nogo-66 receptor; Nogor; NogoR; Nogo-R; Reticulon 4 receptor; Rtn4r; RTN4R_RAT.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Nogo R
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.

Function:
Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).

Subunit:
Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Similarity:
Belongs to the Nogo receptor family. 
Contains 8 LRR (leucine-rich) repeats. 
Contains 1 LRRCT domain. 
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 65078 Human

Entrez Gene: 65079 Mouse

Entrez Gene: 113912 Rat

Omim: 605566 Human

SwissProt: Q9BZR6 Human

SwissProt: Q99PI8 Mouse

SwissProt: Q99M75 Rat

Unigene: 30868 Human

Unigene: 40149 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.