Anti-Beta cellulin/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Beta cellulin/FITC Conjugated抗体

Anti-Beta cellulin/FITC Conjugated抗体

商家询价

产品名称: Anti-Beta cellulin/FITC Conjugated抗体

英文名称: Anti-Beta cellulin/FITC

产品编号: YB--12864R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-Beta cellulin/FITC Conjugated抗体

产品编号 YB-12864R-FITC
英文名称 Anti-Beta cellulin/FITC
中文名称 FITC标记的β细胞素抗体
别    名 Beta cellulin; Beta cellulin precursor; BTC; BTC_HUMAN; OTTHUMP00000160600; OTTHUMP00000219057; Probetacellulin.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  生长因子和激素  淋巴细胞  b-淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 9/17kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Betacellulin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, was originally identified as a growth-promoting factor in the conditioned medium of a mouse pancreatic-cell carcinoma (insulinoma) cell line and has since been identified in humans. BTC is synthesized as a large transmembrane precursor molecule that can be cleaved proteolytically to release the soluble form of BTC or function as membrane-anchored growth factors in juxtacrine signaling. BTC, in addition to stimulating homodimers of ErbB-1 and ErbB-4, is capable of binding and activating all possible combinations of heterodimeric ErbB receptors including the oncogenic ErbB-2/ErbB-3 complex. BTC is also expressed in some human malignancies and may have an important role in tumor growth progression.

Function:
Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the EGF receptor and other related receptors.

Subunit:
Monomer. Interacts with EGFR and ERBB4.

Subcellular Location:
Cell membrane and Secreted > extracellular space.

Tissue Specificity:
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.

Similarity:
Contains 1 EGF-like domain.

Database links:
UniProtKB/Swiss-Prot: P35070.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications