Anti-splicing factor 1/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-splicing factor 1/FITC Conjugated抗体

Anti-splicing factor 1/FITC Conjugated抗体

商家询价

产品名称: Anti-splicing factor 1/FITC Conjugated抗体

英文名称: Anti-splicing factor 1/FITC

产品编号: YB--17679R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-splicing factor 1/FITC Conjugated抗体

产品编号 YB-17679R-FITC
英文名称 Anti-splicing factor 1/FITC
中文名称 FITC标记的剪接因子1抗体
别    名 BBP; D11S636; Mammalian branch point-binding protein mBBP; OTTHUMP00000069749; OTTHUMP00000069750; OTTHUMP00000069752; splicing factor 1; SF01_HUMAN; Transcription factor ZFM1; ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162; ZNF162.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  转录调节因子  锌指蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Danio
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human splicing factor 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Function:
SF1 contains 1 KH domain, 1 CCHC type zinc finger, a nuclear transport domain and glutamine and proline rich regions. It is necessary for the ATP dependent first step of spliceosome assembly and binds to the intron branch point sequence (BPS) 5' UACUAAC 3' of the pre mRNA. It may act as transcription repressor. There are 6 named isoforms produced by alternative splicing.

Subcellular Location:
Nuclear

Tissue Specificity:
Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.

Post-translational modifications:
Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.

Similarity:
Belongs to the BBP/SF1 family. 
Contains 1 CCHC-type zinc finger. 
Contains 1 KH domain.

Database links:

Entrez Gene: 7536 Human

Entrez Gene: 22668 Mouse

Omim: 601516 Human

SwissProt: Q15637 Human

SwissProt: Q64213 Mouse

Unigene: 502829 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications