Anti-PKN/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-PKN/FITC Conjugated抗体

Anti-PKN/FITC Conjugated抗体

商家询价

产品名称: Anti-PKN/FITC Conjugated抗体

英文名称: Anti-PKN/FITC

产品编号: YB--4320R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-PKN/FITC Conjugated抗体

产品编号 YB-4320R-FITC
英文名称 Anti-PKN/FITC
中文名称 FITC标记的蛋白激酶C相关激酶1抗体
别    名 DBK; DPKN; PAK 1; PRK 1; PROTEIN KINASE C RELATED KINASE 1; SERINE/THREONINE PROTEIN KINASE N; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 104kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PKN
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Function:
Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). Plays a role in regulating Rho-mediated dorsal closure during embryogenesis.

Subunit:
Interacts (via N-terminus) with Rho1 (via REM repeats), Rac1 (via REM 1 repeat) and Rac2.

Subcellular Location:
Cytoplasmic.

Post-translational modifications:
Phosphorylated (By similarity). Autophosphorylated; autophosphorylation is stimulated by GTP-bound Rho/Rac GTPases.

Similarity:
Belongs to the protein kinase superfamily. 
Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 C2 domain.
Contains 1 protein kinase domain.
Contains 3 REM (Hr1) repeats.

Database links:

Entrez Gene: 5585 Human

Entrez Gene: 320795 Mouse

Entrez Gene: 29355 Rat

SwissProt: Q16512 Human

SwissProt: P70268 Mouse

SwissProt: Q63433 Rat

SwissProt: Q6P748 Rat

Unigene: 466044 Human

Unigene: 213000 Mouse

Unigene: 49880 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications