Anti-Wnt3 Monoclonal Antibody

英文名称	Anti-Wnt3 Monoclonal Antibody
宿主	Mouse
别名	INT4;TETAMS
应用	WB
稀释比例	WB 1:1000.
交叉反应	Transfected
蛋白分子量	40kDa
Gene ID	7473
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	lgG1
免疫原	Purified recombinant human Wnt3 protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human Wnt3 protein fragments expressed in E.coli.
Subcellular Locations	Secreted extracellular matrix extracellular space
Swiss Prot	P56703
克隆号	4F11-H1-F4
克隆类型	Monoclonal Antibody
背景资料	The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.