Anti-TLR3 Monoclonal Antibody

品牌：solarbio | 货号：K000177M

宿主	Mouse
英文名称	Anti-TLR3 Monoclonal Antibody
别名	CD283;IIAE2;Toll-like receptor 3
应用	WB
稀释比例	WB 1:1000.
蛋白分子量	73/104kDa
Gene ID	7098
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG2b
免疫原	Purified recombinant human TLR3 protein fragments expressed in E.coli.
性状	液体
Subcellular Locations	Early endosome Endoplasmic reticulum membrane Endosome membrane Single-pass type I membrane protein
Swiss Prot	O15455
克隆号	2F10-B8-G9
克隆类型	Monoclonal Antibody
背景资料	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.