Lactacystin

  • 来源:上海康成生物工程有限公司
  • 时间: 2008/1/30
  • 浏览人数: 2560

    Lactacystin

     

    Catalog No: KC-4L002

    Size: 0.2 mg

     

    Physical Appearance:  White solid

     

    Molecular Formula:  C15H24N2O7S

     

    Molecular Weight:  376.4

     

    Purity:  99% (NMR)

     

    Solubility:  Soluble in water (10mg/ml)

     

    Storage:  Store, as supplied, at -20°C for up to 1 year.  Store solutions at -20°C for up to 3 months.

     

    Description:  A potent and selective proteasome inhibitor which affects all three ATP-independent activities of 2OS proteasome (inhibitions of chymotrypsin- and trypsin-like are irreversible; pep.glu-like is reversible). Highly specific, viz. 100µM has no effect on chymotrypsin, trypsin or papain after 48 hrs. Radiolabeling of cells/crude extracts labels primarily X/MB1 proteasome subunit (24 kD) and to a lesser extent, the proteasome α-chain (~30kD). Inhibits NF-κB activation (IC50 = 10µM). Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells. The product is not sterile.

     

    References:

    1.      G. Fenteany et al. Science 1995 268 726

    2.      J. Adams and R. Stein Am.Rep.Med.Chem. 1996 31 279

    3.      G. Fenteany et al. Proc. Natl. Acad. Sci.USA 1994 91 3358

     

    The pharmacological and toxicological properties of this product have not been fully investigated.  Exercise caution in use and handling. This product must not be used in humans.

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