SP600125

  • 来源:上海康成生物工程有限公司
  • 时间: 2008/1/30
  • 浏览人数: 3768

    SP600125

    Anthra[1,9-cd]pyrazol-6(2H)-one

     

    Catalog No: KC-4S004

    Size: 5 mg

     

    Physical Appearance:  Yellow solid

     

    Molecular Formula:  C14H8N2O

     

    Molecular Weight:  220.2

     

    Purity:  99%(TLC)

     

    Solubility:  Soluble in DMSO (20 mM)

     

    Storage:  Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.

     

    Description:  A novel potent and selective JNK-1,-2,-3 inhibitor, IC50=0.11 µM. SP600125 is a reversible ATP competitive inhibitor with >20 fold selectivity versus a range of kinases2. It dose-dependently inhibits the phosphorylation of c-jun and the expression of inflammatory genes COX-2, IL-2, IFN-γ and TNF-α. In vivo, it blocks LPS-induced expression of TNF-α and inhibits anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

     

    References:

    1.      B.L.Bennett et al. Proc. Natl. Acad. Sci. USA 2001 98 13681

    2.      H.Han et al. J. Clin. Invest. 2001 108 73

     

    The pharmacological and toxicological properties of this product have not been fully investigated.  Exercise caution in use and handling.  This product must not be used humans.

     

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