- 时间: 2008/1/30
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Catalog No: KC-4S005
Size: 5 mg
Physical Appearance: White solid
Molecular Formula: C21H16FN3OS
Molecular Weight: 377.4
Purity: >99% (TLC)
Solubility: Soluble in DMSO (50 mg/ml)
Storage: Freezer (-20℃). Protect from light. Following reconstitution, aliquot and freeze (-20℃). This product is stable for 5 years as supplied. Stock solution are stable for up to 6 months at -20℃.
Description: A highly specific, cell-permeable inhibitor of p38 kinase (IC50=34nM in vitro, 600nM in cells). Inhibition is competibive with ATP (Ki=21nM). Inhibites p38 MAPK stimulation of MAPKAPK2 (IC50=70nm). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100μM Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50=50-100nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.
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The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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