Triciribine

  • 来源:上海康成生物工程有限公司
  • 时间: 2008/1/30
  • 浏览人数: 3839

    Triciribine

    35943-35-2 Tricyclic nucleoside(TCN)

    NSC-154020

    API-2

     

    Catalog No: KC-4T001

    Size: 1 mg

     

     

     

    Physical Appearance:  Pale yellow solid

     

    Molecular Formula:  C13H16N6O4

     

    Molecular Weight:  320.3

     

    Purity:  99% (HPLC)

     

    Solubility:  DMSO

     

    Storage:  Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

     

    Description:  Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt1. In whole cells triciribine is phosphorylated by adenosine kinase which may be necessary for its activity.

     

    References:

    1.      L. Yang et al. Cancer Res. 2004 64 4394

    2.      E.C. Moore et al. Biochem. Pharmacol. 1989 38 4037

    3.      R.A. Porcari et al. J. Med. Chem. 2000 43 2438

     

    The pharmacological and toxicological properties of this product have not been fully investigated.  Exercise caution in use and handling.  This product must not be used in humans.

     

     

     

     

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