Triciribine

Triciribine 35943-35-2 Tricyclic nucleoside(TCN) NSC-154020 API-2   Catalog No: KC-4T001 Size: 1 mg

Physical Appearance:  Pale yellow solid

Molecular Formula:  C₁₃H₁₆N₆O₄

Molecular Weight:  320.3

Purity:  99% (HPLC)

Solubility:  DMSO

Storage:  Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Description:  Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt1. In whole cells triciribine is phosphorylated by adenosine kinase which may be necessary for its activity.

References:

1.      L. Yang et al. Cancer Res. 2004 64 4394

2.      E.C. Moore et al. Biochem. Pharmacol. 1989 38 4037

3.      R.A. Porcari et al. J. Med. Chem. 2000 43 2438

The pharmacological and toxicological properties of this product have not been fully investigated.  Exercise caution in use and handling.  This product must not be used in humans.

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