Squalamine lactate 氨基甾醇

来源: 上海皓元生物医药科技有限公司   2019-12-31   访问量:493评论(0)

产品介绍:

Squalamine lactate 是一种从角鲨体内分到的氨基甾醇,具有抗菌活性,同时可用于新生血管性年龄相关性黄斑变性的研究。

作用原理:

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

In Vitro

Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].


In Vivo

Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].

参考文献:

1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246.

[2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88.

Squalamine lactate




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