PeproTech重组小鼠Adiponectin 500ug
产品名称: PeproTech重组小鼠Adiponectin 500ug
英文名称: Recombinant Murine Adiponectin
产品编号: 315-26
产品价格: 0
产品产地: 美国
品牌商标: PeproTech
更新时间: null
使用范围: null
美国PeproTech(派普泰克)公司中国代表处
- 联系人 :
- 地址 :  江苏省苏州市工业园区星湖街218号A1北座4楼L03
- 邮编 : 215123
- 所在区域 : 江苏
- 电话 :
- 传真 : 0512-68325993
- 邮箱 : peprotech.infochina@thermofisher.com
Recombinant Murine Adiponectin
Catalog Number:315-26Synonyms:Acrp-30, GBP-28, Apm-1Description:Adiponectin is an adipose-derived secreted protein containing 236 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-β and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Val-21 to Asn-247 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35.0 kDa by SDS PAGE analysis under reducing conditions.AA Sequence:RGHHHHHHHH VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG RDGTPGEKGE KGDAGLLGPK GETGDVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTNSource:Hi-5 Insect cellsPurity:Greater than 95% by SDS-PAGE gel and HPLC analyses.Biological Activity:Determined by a cytotoxic assay using M1 cells. The ED50 for this effect is 4.0-6.0 μg/ml.Research Interests:Country of Origin:USAResearch Use Only. Not for use in diagnostic or therapeutic procedures.