crystalline-相关检验试剂-试剂-生物在线
crystalline

crystalline

商家询价

产品名称: crystalline

英文名称: crystalline

产品编号: N7878-10G

产品价格: 0

产品产地: 美国

品牌商标: sigma

更新时间: null

使用范围: null

北京普利智诚生物技术有限公司
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  • 地址 : 北京市海淀区清河安宁庄东路海洋出版社院内1号楼一层(银海洋宾馆院内)
  • 邮编 : 100085
  • 所在区域 : 北京
  • 电话 : 138****4438
  • 传真 : 010-82433998
  • 邮箱 : mengzhichengzklm@126.com

Application

Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate of bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is used to study nitrofurantoin-induced toxicity 1 and antiobiotic resistance2.

Biochem/physiol Actions

Nitrofurantoin is activated by bacterial flavoproteins (nitrofuran reductase) to active reduced reactive intermediates that modulate and damage ribosomal proteins or other macromolecules, such as DNA. This inhibits DNA, RNA, protein, and cell wall synthesis which causes cell death3. Nitrofurantoin has a low resistance potential that is rapidly metabolized by mammals and is active against both Gram-positive and Gram-negative bacteria. It is also a pro-oxidant that is cytotoxic due to the generation of intracellular H 2O 2. It is an inhibitor of glutathione reductase. Nitrofurantoin produces hepatotoxicity caused by the redox cycling of the nitro group and its radical anion which leads to oxidative stress1.

form   crystalline
color   yellow