Recombinant  Human IL-9
 
Catalog  Number:
AF-200-09
Synonyms:
p40  cytokine, T-cell growth factor p40
Description:
IL-9  is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes.   IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor  cells and megakaryoblastic leukemia cell lines.  Over-expression of IL-9 has  been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s  disease.  Whereas murine IL-9 can function on human cells, human IL-9 is  inactive on mouse cells.  Recombinant human IL-9 is a 14.0 kDa protein of 127  amino acid residues including 10 cysteine residues which are fully conserved  between the human and murine proteins. Manufactured using all non-animal  reagents.
AA  Sequence:
MQGCPTLAGI LDINFLINKM QEDPASKCHC SANVTSCLCL GIPSDNCTRP  CFSERLSQMT NTTMQTRYPL IFSRVKKSVE VLKNNKCPYF SCEQPCNQTT AGNALTFLKS LLEIFQKEKM  RGMRGKI
Source:
E.coli
Purity:
Greater  than 98% by SDS-PAGE gel and HPLC analyses.
Biological  Activity:
Determined  by its ability to stimulate the proliferation of human MO7e cells. The expected  ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x  106 units/mg.
 
 
 
 
Cross  Reactivity:
Human,  Mouse
Research  Interests:
 
 
 
 
Cancer
 
 
Proliferation
 
 
Country  of Origin:
USA
Research  Use Only. Not for use in diagnostic or therapeutic procedures.