Recombinant Murine FGF-23

Catalog Number:450-55

Synonyms:

Fibroblast growth factor-23

Description:

FGF家族通过促进细胞的增殖和分化，在胎儿发育和产后生长，以及各种组织的再生过程中发挥着重要作用。FGF-23，FGF-21和FGF-19组成非典型的FGF亚家族，该家族的配体作为循环激素，以Klotho蛋白作为辅助受体来传递信号。FGF-23是一种骨源性激素，可以调节肾脏中磷酸盐的动态平衡和维生素D的代谢。FGF-23信号传导的受体，即一种Klotho-FGFR1(IIIc) 复合物，是肾脏磷酸钠共转运体和关键的维生素D代谢酶CYP27B1和CYP24A1的重要调节物。重组小鼠FGF-23是分子量为25.5 kDa的球蛋白，含有228个氨基酸残基。

A Sequence:MYPDTSPLLG SNWGSLTHLY TATARTSYHL QIHRDGHVDG TPHQTIYSAL MITSEDAGSV VITGAMTRRF LCMDLHGNIF GSLHFSPENC KFRQWTLENG YDVYLSQKHH YLVSLGRAKR IFQPGTNPPP FSQFLARRNE VPLLHFYTVR PRRHTRSAED PPERDPLNVL KPRPRATPVP VSCSRELPSA EEGGPAASDP LGVLRRGRGD ARGGAGGADR CRPFPRFV

Source:E.coli

Purity:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.5 μg/ml, in the presence of murine Klotho and heparin.