Biotinylated Human CD19, Fc Tag, ultra sensitivity (primary amine labeling)北京百普赛斯生物科技有限公司

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产品名称: Biotinylated Human CD19, Fc Tag, ultra sensitivity (primary amine labeling)
英文名称: Biotinylated Human CD19, Fc Tag, ultra sensitivity (primary amine labeling)
产品货号: CD9-H8259
产品规格: 200ug
试剂级别: 试剂级
产品产地: USA
产品商标: ACROBiosystems
价    格: 13800元
保存与运输: 保存:-20℃运输:粉末,常温
现货状态: 现货
产品资料: 实验方法技术资料
更新时间: 2017-1-20 17:18:00
浏览人数:740
诚信指数:427点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京百普赛斯生物科技有限公司
地址:
北京经济技术开发区地盛中路3号B座109
邮编:
100176
电话:
400-682-2521
传真:
+86 10-6580-0635
联系人:
张女士
所在区域:
北京·北京
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产品详细描述

分子量:56.3 kDa

纯度:>95% as determined by reduced SDS-PAGE. 

内毒素:Less than 1.0 EU per μg by the LAL method.

Buffer:PBS, pH7.4

生物活性:Measured by its binding ability in a functional ELISA against immobilized FMC63 mAb (0.2 μg/well). The linear range is 0.15-2.5 μg/mL.

产品特性:This protein carries a human IgG1 Fc fragment at the C-terminus. The protein has a calculated MW of 56.3 kDa. The protein migrates as 56-66 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.

产品背景:B-lymphocyte antigen CD19, is a single-pass type Imembrane protein which contains twoIg-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2. 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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