IL-4, Porcine-细胞/细菌培养-试剂-生物在线
IL-4, Porcine

IL-4, Porcine

商家询价

产品名称: IL-4, Porcine

英文名称:

产品编号: CB055-1962

产品价格: 0

产品产地: 美国

品牌商标: ExCell Bio

更新时间: null

使用范围: null

上海吉泰依科赛生物科技有限公司
  • 联系人 :
  • 地址 : 上海市徐汇区桂平路481号18号楼5层
  • 邮编 : 200233
  • 所在区域 : 上海
  • 电话 : 021-6439-8855
  • 传真 : (86 21)33676258
  • 邮箱 : marketing@excellbio.com

Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It has important effects on the growth and differentiation of different immunologically competent cells. Interleukin-4 is produced by mast cells, T cells, and bone marrow stromal cells [1]. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 has numerous important biological functions including stimulating B-cells activation, T-cell proliferation and CD4+ T-cells differentiation to Th2 cells. It is a key regulator in hormone control and adaptive immunity [2]. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells [3]. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure [4]. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure with 2 overhand connections and fall into a 2-stranded anti-parallel beta sheet [5].