Hsp70-derived octapeptide浙江鸿拓生物技术有限公司

性能参数

产品名称: Hsp70-derived octapeptide
英文名称: Hsp70-derived octapeptide
产品货号: ONP10739
产品规格: 1mg
试剂级别: 试剂级和细胞培养级
产品产地: 中国,杭州
产品商标: Ontores
价    格: 315元
保存与运输: 以冻干粉的形式在-20℃下避光保存
现货状态: 100mg
产品资料: 实验方法技术资料
更新时间: 2019/6/6 11:01:00
浏览人数:65
诚信指数:175点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

浙江鸿拓生物技术有限公司
地址:
上海浦东新区蔡伦路781号A1201室(上海办事处)
邮编:
201203
电话:
18575257060
传真:
0571-8886 3303
联系人:
张华光
所在区域:
上海·上海
邮件:
公司展台:

产品详细描述

A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus of hsc70-interacting protein (CHIP), TPR1 and human glutamine-rich TPR-containing protein (hSGT), on refolding of luciferase by DnaJ and hsc70 was investigated. These proteins inhibited the restoration of luciferase activity by the chaperones. The inhibitory effect exerted by TPR1 and hSGT depended upon their binding to hsc70. However, the interaction with hsc70 did not appear to be required for the inhibition of luciferase refolding by CHIP. We also demonstrate that the peptide, GPTIEEVD, corresponding to the C-terminal end of hsc70, abolished the association of [(3)H]hsc70 with CHIP, TPR1 and hSGT. This implied that the GPTIEEVD motif of hsc70 was responsible for interacting with these TPR-containing proteins. However, the GGXP-repeats (where X is any aliphatic residue), another C-terminal conserved motif of vertebrate hsc70s, were not essential for interacting with the TPR-containing proteins. On the basis of mutagenesis studies, it was clear that a unique combination of the functional groups in the GPTIEEVD motif were utilized to interact with each TPR-containing protein, suggesting that inhibitors can be designed and used to elucidate the functional role of these interactions. 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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