AG Scientific|B-1183|Bafilomycin A1
产品名称： AG Scientific|B-1183|Bafilomycin A1
英文名称： Bafilomycin A1
产品编号： B-1183
产品价格： 0
产品产地： 美国
品牌商标： AG Scientific
更新时间： null
使用范围： null
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Useful in distinguishing among different types of ATPases. Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Post-endocytic sorting of calcitonin Receptor-like Receptor and Receptor Activity-Modifying Protein 1. V-ATPase inhibition prevents recovery from anoxia in Artemia franciscana embryos: quiescence signaling through dissipation of proton gradients. V-ATPase expression during development of Artemia franciscana embryos: the potential role for proton gradients in anoxia signaling.
Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.
The inhibitors that act on the late stage of autophagy include chloroquine (CQ), bafilomycin A1, leupeptin, and pepstatin. These latter compounds either inhibit the fusion of autophagosomes with lysosomes or the degradation of autolysosomes.
Synonyms Baf-A1, Baf
Product # B-1183
CAS # 88899-55-2
Chemical Name (2Z,4E,6R,7S,8S,10E,12E,14S,15R)-15-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-DIHYDROXY-5-METHYL-6-PROPAN-2-YLOXAN-2-YL]-3-HYDROXYPENTAN-2-YL]-7-HYDROXY-2,14-DIMETHOXY-4,6,8,10-TETRAMETHYL-16-OXACYCLOHEXADECA-2,4,10,12-TETRAEN-1-ONE
Formula C35H58O9
MW 622.8
Appearance White Solid
Purity 95%
Solubility Soluble in ethanol (1:250), DMSO (10 mg/ml), 0.1 M NaOH, methanol (3.2 mg/ml), DMF (50 mg/ml), and alkaline solutions. Insoluble in water
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use Bafilomycin A1 inhibit macroautophagy and promote apoptosis in colon cancer cells
MDL Number MFCD06795130
ChemACX X1087211-6
InChI InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
SMILES C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.
The inhibitors that act on the late stage of autophagy include chloroquine (CQ), bafilomycin A1, leupeptin, and pepstatin. These latter compounds either inhibit the fusion of autophagosomes with lysosomes or the degradation of autolysosomes.
Synonyms Baf-A1, Baf
Product # B-1183
CAS # 88899-55-2
Chemical Name (2Z,4E,6R,7S,8S,10E,12E,14S,15R)-15-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-DIHYDROXY-5-METHYL-6-PROPAN-2-YLOXAN-2-YL]-3-HYDROXYPENTAN-2-YL]-7-HYDROXY-2,14-DIMETHOXY-4,6,8,10-TETRAMETHYL-16-OXACYCLOHEXADECA-2,4,10,12-TETRAEN-1-ONE
Formula C35H58O9
MW 622.8
Appearance White Solid
Purity 95%
Solubility Soluble in ethanol (1:250), DMSO (10 mg/ml), 0.1 M NaOH, methanol (3.2 mg/ml), DMF (50 mg/ml), and alkaline solutions. Insoluble in water
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use Bafilomycin A1 inhibit macroautophagy and promote apoptosis in colon cancer cells
MDL Number MFCD06795130
ChemACX X1087211-6
InChI InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
SMILES C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C