PeproTech重组人Sclerostin 500ug美国PeproTech(派普泰克)公司中国代表处

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产品名称: PeproTech重组人Sclerostin 500ug
英文名称: Human Sclerostin
产品货号: 100-49-500
产品规格: 500ug
试剂级别: 细胞培养级
产品产地: 美国
产品商标: PeproTech(派普泰克)
价    格: 询价元
保存与运输: 低温
现货状态: 现货请询
产品资料: 实验方法技术资料
更新时间: 2017-11-14 17:07:00
浏览人数:6
诚信指数:942点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

美国PeproTech(派普泰克)公司中国代表处
地址:
江苏省苏州市高新区玉山路99号钻石广场2幢416室
邮编:
215021
电话:
0512-68325983
传真:
0512-68325993
联系人:
贾俊霞
所在区域:
江苏·苏州
邮件:
公司展台:
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产品详细描述

Description:
Sclerostin, a glycoprotein predominantly secreted by osteocytes, is a member of the Cerberus/DAN family of putative BMP antagonists that functions as an endogenous regulator of the canonical Wnt signaling pathway and an inhibitory regulator of bone homeostasis. Although expressed nearly exclusively by osteocytes, sclerostin can also be found at significant levels elsewhere, such as bone, bone marrow, cartilage, the kidney, and the liver, and has also been shown to be produced by hypertrophic chondrocytes and cementocytes. Like DKK family members DKK-1 and DKK-4, sclerostin plays an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL Receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. Sclerostin has also been shown to interact directly with LRP4 via its extracellular domain to facilitate inhibition of Wnt signaling, and can catabolically promote osteoclast activity by increasing osteocyte expression of RANKL. Sclerostin’s critical involvement in the regulation of bone formation and resorption is emphasized by two bone dysplasia disorders, sclerosteosis and van Buchem disease (VBD), caused by rare autosomal recessive mutations that result in progressive bone overgrowth and hypermineralization due to markedly decreased sclerostin levels. PeproTech'sCHO cell-derived Recombinant Human Sclerostin is a 186-amino-acid-length glycoprotein with a calculated molecular weight of 21.0 kDa. As a result of glycosylation, Recombinant Human Sclerostin migrates with an apparent molecular mass of approximately 26-32 kDa by SDS-PAGE gel, under non-reducing conditions.

Source:CHO cells

Synonyms:SOST, SOST1, CDD, VBCH, DAND6

AA Sequence:AFKNDATEII PELGEYPEPP PELENNKTMN RAENGGRPPH HPFETKDVSE YSCRELHFTR YVTDGPCRSA KPVTELVCSG QCGPARLLPN AIGRGKWWRP SGPDFRCIPD RYRAQRVQLL CPGGEAPRAR KVRLVASCKC KRLTRFHNQS ELKDFGTEAA RPQKGRKPRP RARSAKANQA ELENAY

Purity:Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Determined by its ability to downregulate alkaline phosphatase activity in differentiating MC3T3E1 cells in the presence of 20ng/ml murine Wnt3a.

Country Of Origin:USA

Research Use Only: Not for use in diagnostic or therapeutic procedures. 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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