性能参数
产品名称: PeproTech重组人sTNF Receptor Type I(无动物成分) 5ug
英文名称: Human sTNF Receptor Type I
产品货号: AF-310-07-5
产品规格: 5ug
试剂级别: 细胞培养级
产品产地: 美国
产品商标: PeproTech(派普泰克)
价 格: 询价元
保存与运输: 低温
现货状态: 现货请询
产品资料: 实验方法技术资料
更新时间: 2018/2/17 13:28:00
浏览人数:19
诚信指数:954点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。
产品详细描述
Description: TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein. Manufactured using all Animal-Free reagents. Source:E.coli Synonyms:soluble Tumor Necrosis Factor Type I, TNFRSF1A, TNFAR, p60, p55, CD120a, TNFR1 AA Sequence:MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses. Biological Activity:Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-α, is 0.05 g/ml. Country Of Origin:USA Research Use Only: Not for use in diagnostic or therapeutic procedures.
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。
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