PeproTech重组人sTNF Receptor Type I(无动物成分) 1000ug-蛋白纯化-试剂-生物在线
PeproTech重组人sTNF Receptor Type I(无动物成分) 1000ug

PeproTech重组人sTNF Receptor Type I(无动物成分) 1000ug

商家询价

产品名称: PeproTech重组人sTNF Receptor Type I(无动物成分) 1000ug

英文名称: Human sTNF Receptor Type I

产品编号: AF-310-07-1000

产品价格: 0

产品产地: 美国

品牌商标: PeproTech(派普泰克)

更新时间: null

使用范围: null

美国PeproTech(派普泰克)公司中国代表处
  • 联系人 :
  • 地址 :  江苏省苏州市工业园区星湖街218号A1北座4楼L03
  • 邮编 : 215123
  • 所在区域 : 江苏
  • 电话 :
  • 传真 : 0512-68325993
  • 邮箱 : peprotech.infochina@thermofisher.com

Description:
TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein.

Manufactured using all Animal-Free reagents.

Source:E.coli

Synonyms:soluble Tumor Necrosis Factor Type I, TNFRSF1A, TNFAR, p60, p55, CD120a, TNFR1

AA Sequence:MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN

Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-α, is 0.05 g/ml.

Country Of Origin:USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.