PeproTech重组小鼠IL-21(无动物成分) 1000ug-蛋白纯化-试剂-生物在线
PeproTech重组小鼠IL-21(无动物成分) 1000ug

PeproTech重组小鼠IL-21(无动物成分) 1000ug

商家询价

产品名称: PeproTech重组小鼠IL-21(无动物成分) 1000ug

英文名称: Murine IL-21

产品编号: AF-210-21-1000

产品价格: 0

产品产地: 美国

品牌商标: PeproTech(派普泰克)

更新时间: null

使用范围: null

美国PeproTech(派普泰克)公司中国代表处
  • 联系人 :
  • 地址 :  江苏省苏州市工业园区星湖街218号A1北座4楼L03
  • 邮编 : 215123
  • 所在区域 : 江苏
  • 电话 :
  • 传真 : 0512-68325993
  • 邮箱 : peprotech.infochina@thermofisher.com

Description:
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in nave B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues.

Manufactured using all Animal-Free reagents.

Source:E.coli

Synonyms:Interleukin-21, Za11

AA Sequence:MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS

Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expectedED50is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.

Country Of Origin:USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.