Human CD19 (20-291) Protein, His Tag北京百普赛斯生物科技有限公司

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产品名称: Human CD19 (20-291) Protein, His Tag
英文名称: Human CD19 (20-291) Protein, His Tag
产品货号: CD9-H52H2
产品规格: 50ug,500ug
产品产地: USA
产品商标: ACROBiosystems
价    格: 3200,21100元
保存与运输: -20
产品资料: 实验方法技术资料
更新时间: 2017-12-5 14:46:00
浏览人数:18
诚信指数:475点
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使用范围:仅限科研使用,不能应用于临床
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北京百普赛斯生物科技有限公司
地址:
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100176
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400-682-2521
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010-58043677
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所在区域:
北京·北京
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产品详细描述

 内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Immobilized FMC63 MAb at 2 μg/mL (100 μL/well) can bind Human CD19, His Tag (Cat. No. CD9-H52H2) with a linear range of 10-78 ng/mL (QC tested).

产品背景:
B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I  membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2.


产品描述:
Human CD19 (20-291), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SDS-PAGE


 

因为难以在供应系统上进行数据同步,所以了解更多产品规格及产品数据,请移步:

http://www.acrobiosystems.cn/P1150-Human_CD19_20-291_Protein_His_Tag.html

订购方式
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电话:400-682-2521  
网址:http://www.acrobiosystems.cn
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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