Less than 1.0 EU per μg by the LAL method.
>95% as determined by SDS-PAGE.
Immobilized Human CD40, His Tag (Cat. No. CD0-H5228) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD40 Ligand, Fc Tag (Cat. No. CDL-H82F1) with a linear range of 1-31 ng/mL (QC tested).
CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines.
Biotinylated Human CD40 Ligand, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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