Less than 1.0 EU per μg by the LAL method.
>95% as determined by SDS-PAGE.
Immobilized Human IL-17A & IL-17F, His Tag, Strep Tag (Cat. No. ILF-H52WF) at 2 μg/mL (100 μL/well) can bind Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) with a linear range of 39-625 ng/mL (QC tested).
Immobilized Anti-IL17A Mab Human IgG1 at 2 μg/mL (100 μL/well) can bind Human IL-17A & IL-17F, His Tag, Strep Tag (Cat. No. ILF-H52WF) with a linear range of 0.2-3 ng/mL (Routinely tested).
Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Human IL-17A & IL-17F Heterodimer Protein on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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