PeproTech重组人PD-L2 Fc 500ug美国PeproTech(派普泰克)公司中国代表处

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性能参数

产品名称: PeproTech重组人PD-L2 Fc 500ug
英文名称: Recombinant Human PD-L2 Fc
产品货号: 310-38-500
产品规格: 500ug
试剂级别: 细胞培养级
产品产地: 美国
产品商标: PeproTech(派普泰克)
价    格: 询价元
保存与运输: 低温
现货状态: 现货请询
产品资料: 实验方法技术资料
更新时间: 2018/8/12 13:23:00
浏览人数:10
诚信指数:982点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

美国PeproTech(派普泰克)公司中国代表处
地址:
 江苏省苏州市工业园区星湖街218号A1北座4楼M10
邮编:
215123
电话:
0512-68325983,4000053055
传真:
0512-68325993
联系人:
贾俊霞
所在区域:
江苏·苏州
邮件:
公司展台:
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产品详细描述

Catalog Number:
310-38
Description:
Programmed death-ligand 2 (PD-L2), or B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily that, along with programmed death-ligand 1 (PD-L1), acts as a ligand for programmed cell death prote1 (PD-1). Though expressed primarily in dendritic cells, PD-L2 expression can be induced on a wide variety of immune and non-immune cells depending on the microenvironment. PD-L2 expression is particularly upregulated in the presence of Th2 cytokine, IL-4, as well as Th1 cytokines, TNF-α and IFN-γ to a lesser degree. While generally expressed at lower levels compared to PD-L1, PD-L2 demonstrates a 2 to 6 times higher relative affinity to PD-1 than PD-L1. PD-1 and its ligands are referred to as inhibitory immune checkpoint molecules in that they provide useful negative feedback during physiological homeostasis. Ligation of PD-L2 or PD-L1 inhibits activation, proliferation, and cytokine secretion (e.g. IFN-gamma, IL-10) in T cells, ultimately dampening immune response. Conversely, studies have shown that PD-L2 can also stimulate T-cell proliferation and cytokine production, even in PD-1-deficient T cells, suggesting additional receptors. Recent studies have concluded that PD-L2 also binds to a second receptor, repulsive guidance molecule b (RGMb), which was originally identified as a receptor for bone morphogenetic proteins (BMPs). RGMb is expressed in the central nervous system, as well as in macrophages, however, its role in immunity is only beginning to emerge. Interaction between PD-L2 and RGMb regulates the development of respiratory tolerance in the lung through BMP and/or neogenin signaling pathways. The naturally occurring human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain. PeproTech’s CHO cell-derived Recombinant Human PD-L2 Fc is a glycosylated, disulfide-linked homodimer of 433-amino-acid residues whose monomer consists of a 200-amino-acid portion of mature PD-L2, including Leu20 through Pro219, fused to the 231-amino-acid length Fc portion of human IgG1 by two glycines. The calculated molecular weight of monomeric CHO cell-derived Recombinant Human PD-L2 Fc is 48.6 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 65-75 kDa by SDS-PAGE analysis under reducing conditions.
Source:
CHO cells
Synonyms:
Programmed cell death 1 ligand 2 (PDCD1 ligand 2), PD-1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, CD273, PDCD1LG2, PDCD1L2, PDLB7DC
AA Sequence (monomer):
LFTVTVPKEL YIIEHGSNVT LECNFDTGSH VNLGAITASL QKVENDTSPH RERATLLEEQ LPLGKASFHI PQVQVRDEGQ YQCIIIYGVA WDYKYLTLKV KASYRKINTH ILKVPETDEV ELTCQATGYP LAEVSWPNVS VPANTSHSRT PEGLYQVTSV LRLKPPPGRN FSCVFWNTHV RELTLASIDL QSQMEPRTHP GGPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
Purity:
≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to bind programmed cell death ligand 1 (PD-1) in a functional ELISA. 

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