Human TIM-3 / HAVCR2 Protein, Mouse IgG2a Fc Tag, low endotoxin北京百普赛斯生物科技有限公司

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产品名称: Human TIM-3 / HAVCR2 Protein, Mouse IgG2a Fc Tag, low endotoxin
英文名称: Human TIM-3 / HAVCR2 Protein, Mouse IgG2a Fc Tag, low endotoxin
产品货号: TM3-H525b
产品规格: 1mg
产品产地: USA
产品商标: ACROBiosystems
价    格: 22000元
现货状态: 大量
产品资料: 实验方法技术资料
更新时间: 2018/4/17 9:37:00
浏览人数:1
诚信指数:587点
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使用范围:仅限科研使用,不能应用于临床
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北京百普赛斯生物科技有限公司
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北京·北京
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产品详细描述

内毒素:
Less than 0.1 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Immobilized Human TIM-3, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. TM3-H525b) at 0.2 μg/mL (100 μL/well) can bind Anti-TIM3 MAb, Human IgG4 with a linear range of 0.2-2 ng/mL (QC tested).

产品背景:
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

产品描述:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 46.8 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
因为难以在供应系统上进行数据同步,所以了解更多产品规格及产品数据,请移步:
http://www.acrobiosystems.cn/P1267-Human_TIM-3_%7C_HAVCR2_Protein_Mouse_IgG2a_Fc_Tag_low_endotoxin.html 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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