Recombinant Murine IL-17D
IL‐17D is a disulfide‐linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17D has the ability to stimulate the production of IL‐6, IL‐8 and GM‐CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony‐forming assays. Recombinant Murine IL‐17D is a 20.2 kDa protein consisting of 184 amino acid residues.
AA Sequence:MAGALRTGRR PARPRDCADR PEELLEQLYG RLAAGVLSAF HHTLQLGPRE QARNASCPAG GRAADRRFRP PTNLRSVSPW AYRISYDPAR FPRYLPEAYC LCRGCLTGLY GEEDFRFRST PVFSPAVVLR RTAACAGGRS VYAEHYITIP VGCTCVPEPD KSADSANSSM DKLLLGPADR PAGR
Purity:≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:Determined by its ability to bind murine IL-17RB Fc Chimera in a functional ELISA.
Country Of Origin: USA
Not for human use.
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