Product Description

XAV939 is a tankyrase (TNKS) inhibitor, most specifically for TNKS1 (IC50 of 5nM) and TNKS2 (IC50 of 2nM) (Haikarainen, et al.), in turn indirectly inhibiting downstream Wnt/β-catenin signaling (Huang, et al.). XAV939 has been shown to be an efficient additive in the derivation of functional neurons from human pluripotent stem cells (PSCs) when combined with other small molecules including LDN193189 (Cat. No. SM-0005-0010) and SB431542 (Cat. No. SM-0009-0010) (Qi, et al.). Additionally, XAV939 allows for the enhanced differentiation of PSCs into cardiomyocytes (Minami, et al.).
 

Product Synonyms:

XAV-939, XAV 939

Constructed from renowned protocols, Biological Industries selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

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