Product Description

Compound E is a potent γ-secretase inhibitor that specifically blocks β-amyloid-40 (IC50 of 0.24), β-amyloid-42 (IC50 of 0.37), and cleavage of the Notch domain (IC50 of 0.32). Compound E has been shown to promote the differentiation of embryonic stem cells (ESCs) to primitive neural precursors in addition to generating a self-renewing progenitor neuroepithelia stem cell population (Li, et al.) when combined with CHIR99021 (Cat. No. SM-0001-0010), SB431542 (Cat. No. SM-0009-0010), and hLIF. Forebrain GABA interneurons have also been derived from human pluripotent stem cells (PSCs) through the utilization of Compound E (Liu, et al.); additionally, it has shown promising effects in Alzheimer’s disease models using iPSC-derived neurons (Yagi, et al.).

Product Synonyms:

XXI, Compound E (secretase inhibitor), DuPont E, C-E, γ-secretase inhibitor XXI, Gamma-secretase inhibitor
Constructed from renowned protocols, Biological Industries selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

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