PCSK9 is a crucial protein in the regulation of plasma cholesterol homeostasis. It binds low density lipoprotein receptor (LDL R) to enhance the degradation of LDL R. Therefore, inhibition of PCSK9 has been considered a promising strategy to prevent the receptor from being degraded and promote removal of LDL cholesterol from circulation.
Application
This pair is useful for screening for inhibitors of human PCSK9 binding to human LDL R.
Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration. 
Storage
 Upon receipt, please store all items at -70℃.
After reconstitution, the stock solution should be kept at -70℃.