HIV p17 Gag (77-85)浙江鸿拓生物技术有限公司

性能参数

产品名称: HIV p17 Gag (77-85)
英文名称: HIV p17 Gag (77-85)
产品货号: ONP10894
产品规格: 1mg
试剂级别: 试剂级和细胞培养级
产品产地: 中国,杭州
产品商标: Ontores
价    格: 693元
保存与运输: 以冻干粉的形式在-20℃下避光保存
现货状态: 100mg
产品资料: 实验方法技术资料
更新时间: 2019/7/5 14:47:00
浏览人数:308
诚信指数:175点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

浙江鸿拓生物技术有限公司
地址:
上海浦东新区蔡伦路781号A1201室(上海办事处)
邮编:
201203
电话:
18575257060
传真:
0571-8886 3303
联系人:
张华光
所在区域:
上海·上海
邮件:
公司展台:

产品详细描述

HIV-1 gag p17 protein is an attractive target for molecular intervention, because it is involved in the viral replication cycle at both the pre- and postintegration levels. In the present experiments, we targeted p17 by intracellularly expressing a cDNA encoding an Ab to p17. cDNA from a hybridoma-secreting Ab to p17 was cloned, sequenced, reconstructed as a single-chain Ab fragment (scFv), and expressed in the cytoplasm or nucleus with appropriate retention signals. The expressed scFvs had no effect on T cell growth or CD4 expression and bound specifically to HIV-1 p17. Human CD4+ Jurkat T cells that expressed scFvs and were infected with HIV-1 showed a marked reduction in virus replication compared with cells expressing vector alone. The inhibition of virus replication was more pronounced when scFvs were expressed in the cytoplasm rather than the nucleus. From these studies, we conclude that the intracellular expression of a single-chain Ab to p17 inhibits HIV replication; in addition, the degree of inhibition is related to the intracellular targeting site. 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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