PeproGMP® Recombinant Human Flt3-Ligand
Catalog Number:
GMP300-19
Description:
Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells.  Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3.  Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation.  Unlike SCF, Flt3-Ligand exerts no activity on mast cells.  Multiple isoforms of Flt3-Ligand have been identified.  The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.).  The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform.
AA Sequence:
MTQDCSFQHS PISSDFAVKI RELSDYLLQD YPVTVASNLQ DEELCGGLWR LVLAQRWMER LKTVAGSKMQ GLLERVNTEI HFVTKCAFQP PPSCLRFVQT NISRLLQETS EQLVALKPWI TRQNFSRCLE LQCQPDSSTL PPPWSPRPLE ATAPTA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
 
 
 
 
Research Interests:


    

        

            

            
Cancer
            

            
Cell Culture
        
        

            

            
Immune System
            

            
Proliferation
        
        

            

            
Stem Cells & Differentiation
            
 
        
    


 
 
Country of Origin:
USA