PeproTech重组人Heregulinβ-1(GMP) 25ug
产品名称: PeproTech重组人Heregulinβ-1(GMP) 25ug
英文名称: PeproGMP Recombinant Human Heregulinβ-1
产品编号: GMP100-03-100
产品价格: 0
产品产地: 美国
品牌商标: PeproTech(派普泰克)
更新时间: null
使用范围: null
美国PeproTech(派普泰克)公司中国代表处
- 联系人 :
- 地址 :  江苏省苏州市工业园区星湖街218号A1北座4楼L03
- 邮编 : 215123
- 所在区域 : 江苏
- 电话 :
- 传真 : 0512-68325993
- 邮箱 : peprotech.infochina@thermofisher.com
Product Details Catalog Number: GMP100-03 Description: Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Additional product information and specifications are provided on the Certificate of Analysis. Manufactured using all Animal-Free reagents. AA Sequence: SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Source: E.coli Regional Note Please contact Customer Service for a quote on our PeproGMP products.