重组小鼠Bcl-xL
产品名称: 重组小鼠Bcl-xL
英文名称: Recombinant Murine B-cell lymphoma-extra large
产品编号: HZ
产品价格: 0
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: null
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
重组小鼠Bcl-xL
附带条件
特技
Bcl-XL是一种跨膜蛋白,位于长寿命和有丝分裂后的细胞线粒体膜中,如脑细胞。它在Fas配体的信号转导通路中发挥作用。Bcl xL是抗凋亡蛋白,是Bcl-2家族的成员,能够形成异源二聚体,这是调控细胞凋亡的重要事件。它与癌细胞的存活有关。Bcl xL是凋亡/活性细胞**的主要监测者。它具有细胞死亡阻遏活性,因此作为生存蛋白。小鼠Bcl-xL分别与人和大鼠Bcl-xL共有97%和99% A.A.序列同源性。
附带条件
该材料由Sangon生物技术公司提供,用于研究、实验室或进一步评估目的。不适合人类使用。
附带条件
物理外观无菌过滤白冻干(冻干)粉末。
纯度为97%以上,采用SDS-PAGE和HPLC分析。
来源大肠杆菌。
生物活性试验。
在2μPBS、pH 7.4、5%海藻糖中用0.2μm过滤浓缩液进行冻干。
LaAl法测定内毒素低于0.1μE/μg的RMUBcl-XL。
我们建议在打开之前将这个小瓶简单地离心,以将内容物带到底部。在含0.1% BSA的无菌蒸馏水或含水缓冲液中重组,浓度为0.1-1.0mg/mL。原料溶液应分摊到工作等分试样中,并储存在小于20℃的温度下,应在适当的缓冲溶液中进一步稀释。
AAA序列SqnRelvVVD FLSYKLQKG
概述
Bcl-xL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays a role in the signal transduction pathway of the FAS-Ligand. Bcl-xL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. It is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. It has cell death repressor activity and therefore acts as a survival protein. The murine Bcl-xL shares 97 % and 99 % a.a. sequence identity with human and rat Bcl-xL, respectively.
使用说明
This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
技术规格
Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity | > 97 % by SDS-PAGE and HPLC analyses. |
Source | Escherichia coli. |
Biological Activity | Test in Process. |
Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH 7.4, 5 % Trehalose. |
Endotoxin | Less than 0.1 EU/μg of rMuBcl-xL as determined by LAL method. |
Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
AA Sequence | SQSNRELVVD FLSYKLSQKG YSWSQFSDVE ENRTEAPEET EAERETPSAI NGNPSWHLAD SPAVNGATGH SSSLDAREVI PMAAVKQALR EAGDEFELRY RRAFSDLTSQ LHITPGTAYQ SFEQVVNELF RDGVNWGRIV AFFSFGGALC VESVDKEMQV LVSRIASWMA TYLNDHLEPW IQENGGWDTF VDLYGNNAAA ESRKGQERFN R |