PeproTech 重组小 C5a美国PeproTech(派普泰克)公司中国代表处

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产品名称: PeproTech 重组小 C5a
英文名称: Recombinant Murine C5a
产品货号: 315-40
产品规格: 5ug/20ug/100ug/250ug/500ug/1000ug
试剂级别: 细胞培养级
产品产地: 美国
产品商标: PeproTech
价    格: 询价元
保存与运输: 低温
现货状态: 现货请询
产品资料: 实验方法技术资料
更新时间: 2019/11/11 9:46:00
浏览人数:107
诚信指数:1104点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

美国PeproTech(派普泰克)公司中国代表处
地址:
 江苏省苏州市工业园区星湖街218号A1北座4楼M10
邮编:
215123
电话:
0512-68325983,4000053055
传真:
0512-68325993
联系人:
贾俊霞
所在区域:
江苏·苏州
邮件:
公司展台:
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产品详细描述

Recombinant Murine C5a

Product Details

Catalog Number:315-40
Description:

Complement 5a (C5a) is an enzymatically generated glycoprotein belonging to the anaphylatoxin family of structurally and functionally related proteins. Generated upon the activation of the complement system, C5a, together with C4a, C3a, and the membrane attack complex (C5b‐9), functions as a central player in host defense by inducing smooth muscle cell contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes through cell degranulation. In addition to acting as a direct mediator of localized inflammatory response, C5a also initiates both the synthesis and release of IL‐8 from monocytes and bronchial epithelial cells, stimulates the proliferation of neurons and hepatocytes, and functions as a potent chemoattractant. Where C5a deficiency, a rare defect of the complement pathway caused by the mutation of the C5a gene, is associated with susceptibility to severe infections, excessive C5a activation has been linked to liver fibrosis, sepsis, adult respiratory distress syndrome, rheumatoid arthritis, Alzheimer’s disease, and ischemic heart disease. Human C5a shares 60% and 54% sequence identity to mouse and rat C5a, respectively. The human C5 gene encodes a 1,676 amino acid glycoprotein that is comprised of a disulfide‐linked C5 alpha and a C5 beta chain, the former of which contains the active, 74 amino acid C5a anaphylatoxin chain. Recombinant Murine C5a is an 8.9 kDa glycoprotein containing the 77 amino acid residues of the C5a anaphylatoxin chain.

Source:E.coli

Synonyms:Complement Component 5a, Complement 5a, CPAMD4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4

AA Sequence:NLHLLRQKIE EQAAKYKHSV PKKCCYDGAR VNFYETCEER VARVTIGPLC IRAFNECCTI ANKIRKESPH KPVQLGR

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Measured by its ability to support adhesion of Human Umbilical Vein Endothelial Cells (HUVEC) to the Recombinant Murine C5a-coated surface.

Country Of Origin: USA

Not for human use.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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