LDN193189 (HCl)-干细胞-试剂-生物在线
LDN193189 (HCl)

LDN193189 (HCl)

商家询价

产品名称: LDN193189 (HCl)

英文名称: LDN193189 (HCl)

产品编号: SM-0005-0010

产品价格: 0

产品产地: 以色列

品牌商标: Biological industries(BI)

更新时间: null

使用范围: null

上海逍鹏生物科技有限公司
  • 联系人 : 市场部
  • 地址 : 上海市浦东新区祖冲之路1505弄80号1幢3楼
  • 邮编 : 200120
  • 所在区域 : 上海
  • 电话 : 189****5545
  • 传真 : 021-58777053
  • 邮箱 : Never.huang@xpbiomed.com

 

Product Description


LDN193189 (HCl) is a highly-potent inhibitor of BMP signaling, specifically blocking ALK1 (IC50 of 0.8 nM), ALK2 (IC50 of 0.8 nM), ALK3 (IC50of 5.3 nM), and ALK6 (IC50 of 16.7 nM), and in turn affecting Smad1/5/8 expression (Galvin-Burgess, et al.). LDN193189 (HCl) has been shown to contribute to the differentiation of pluripotent stem cells (PSCs) into functional pancreatic beta cells when combined with CHIR99021 (Cat. No. SM-0001-0010), SANT-1 (Cat. No. SM-0008-0010), Y27632 (Cat. No. SM-0013-0010), Compound E (Cat. No. SM-0002-0010), RepSox (Cat. No. SM-0006-0010), Triiodothyronine Salt (Cat. No. SM-0011-0500) along with other growth factors (Pagliuca, et al.). LDN193189 has also been utilized in the derivation of neural progenitor cells (Edri, et al.), and cortical neurons (Qi, et al.) from PSCs. 
 

Product Synonyms:

LDN193189 tetrahydrochloride, LDN-193189, 1062368-62-0 

Constructed from renowned protocols, Biological Industries selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

 

 产品官网链接:https://www.bioind.com/worldwide/ldn-193189/

想了解更多种类的小分子,请点击官网:https://www.bioind.com/worldwide/products/stem-cell-research/small-molecules/