Recombinant Rat IL-21

产品详情

IL‐21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen‐specific responses of immune cells. The biological effects of IL‐21 include: inducing the differentiation of T cell‐stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL‐4; and the induction of apoptotic effects in naïve B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL‐21 promotes the anti‐tumor activity of CD8+ T cells and NK cells. IL‐21 exerts its effect through binding to a specific type I cytokine receptor, IL‐21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL‐2, IL‐4, IL‐7, IL‐9 and IL‐15. The IL‐21/IL‐21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Rat IL‐21 is a 15.3 kDa protein containing 130 amino acid residues.

Source:E.coli

Synonyms:Interleukin-21

AA Sequence:MHKSSPQRPD HLLIRLRHLM DIVEQLKIYE NDLDPELLTA PQDVKGQCEH EAFACFQKAK LKPSNTGNNK TFINDLLAQL RRRLPAKRTG NKQRHMAKCP SCDLYEKKTP KEFLERLKWL LQKMIHQHLS

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected ED₅₀ is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁶ units/mg.

Calculated Molecular Weight:15.3 kDa

Accession Number:A3QPB9

Gene ID:365769

Country Of Origin: USA

Not for human use.