离子通道药物的细胞模型高通量筛选服务欧罗拉生物科技有限公司

技术服务信息

服务名称:离子通道药物的细胞模型高通量筛选服务
服务类别:新药研发外包服务 - 离子通道筛选服务
价格:询价
允许参观:不允许参观
所在区域:广东.佛山
更新时间:2017/10/24 9:14:00
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

欧罗拉生物科技有限公司
地址:
顺德大良德胜东路2号奥罗达国际商务科技园
邮编:
528300
电话:
18128753216
传真:
0757-22320293
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市场部
所在区域:
广东·佛山
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技术服务详细描述

 

Assay Services

Aurora Biomed
provides functional assay services on an exclusive, out-sourced basis. 
We are currently carrying out assay services for various ion channel targets including hERG safety screen. Several options for these services exist, we can read/test flux assay samples from your experiments on ICR, we can screen your compounds/library in our laboratories or we can accept cell lines to develop assay for you as part of our services.

Aurora Biomed has a team of highly trained molecular biologists have a solid understanding of ion channels and flux assays. We enjoy a challenge and feel confident in providing solutions to further your ion channel screening needs.

We are pleased to offer both cold flux assays using our proprietary Ion Channel Reader technology and manual voltage-clamp electrophysiology assays. 

Cold flux assays utilize tracer ions to study the ion channel of interest.  The method of detection for Aurora Biomed’s cold flux assays is flame atomic absorption spectroscopy as employed by our proprietary Ion Channel Reader technology.  The Ion Channel Reader Series provides a high throughput format for ion channel screening by the flux assay approach.  The use of high throughput assays helps reduce the burden on electrophysiology by providing some idea of which compounds should be screened if resources are limited and not all compounds can be screened with manual-patch clamp.  The cold flux assay approach is ideal for determining which compounds to follow up with electrophysiology as there is a strong linear correlation (R=0.88) and consistently identical drug rank orders between the two methods.

Manual voltage-clamp electrophysiology is the gold-standard for ion channel screening.  Moreover, the FDA requires in vitro electrophysiology studies in conjunction with in vivo studies for compounds submitted for NDA status.  Oocyte-based studies assess potential cellular mechanisms that may not be evident from in vivo data.

 ICR 12000

The ICR 12000 designed for ultra high throughput screening of compound libraries against ion channel targets. Based on the robustness of Aurora Biomed's ICR technology, the reader offers high sensitivity generating accurate drug rank order matching electrophysiology data. This new member of the ICR series provides the throughput to access compound QT liability early in the drug discovery process.

Technology
The technology is based upon the versatility, precision, and sensitivity of atomic absorption spectroscopy (AAS) and Aurora Biomed's patented microsampling process. Ion Channel Technology is suitable for both ligand-gated and voltage-gated ion channels using cell-based flux assays.


Features

• High Throughput: Up to 60,000 wells/day
• Multi-Channel: Measures 12 samples at a time
• Minimum sample volume: 20 µl
• Accommodation: 96/384-well microplates
• Footprint: H.135 cm X W.134cm X D.97cm
• Fuel Source: Natural Gas / Compressed Air
• Includes: Plate Stacker / Bar Code Reader
• Sensitivity: 0.05 ppm detection limit
• Precision: < 5% CV
Applications

CR technology is suitable for many types of  ion channels broad applications include:

• Shaker (Kv1.1, Kv1.4 and Kv1.5)
• hERG
• KCNQ4
• B/SKCa
• KCNB/TASK-3
• Kir2.1
• nAChR
• KATP (P2X family)

具体请参考我们的网站:http://www.aurorabiomed.com/icr1.htm?pnl=1_3

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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