Rabbit Anti-Syntaxin 6/FITC Conjugated antibody
|STX 6; STX6; STX-6; STX6_HUMAN; Syntaxin-6; Syntaxin6.
|100ul/2980元 购买 大包装/询价
|说 明 书
|细胞生物 神经生物学 信号转导
|Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量
|Lyophilized or Liquid
|免 疫 原
|KLH conjugated synthetic peptide derived from human Syntaxin 6
|affinity purified by Protein A
|储 存 液
|0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
|Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain carboxy-terminal hydrophobic domains that direct themselves to their respective intracellular compartments. Synaptin 6 is a 255 amino acid protein that is widely expressed, with higher expression levels in brain, lung and kidney. This synaptin co-localizes with vesicle associated membrane protein (VAMP) 4 to tubular and vesicular membranes of the Golgi apparatus. The cytosolic domain of Syntaxin 6 reduces the rate on Glut4 reinternalization upon insulin withdrawl and is involved in a memrane-trafficking process that removes Glut4 from traffic directed to the plasma membrane. Syntaxin 6 is upregulated in activated macrophages in conjunction with an increase in the secretion of cytokines. The delivery of microdomain-associated lipids and proteins to the cell surface is regulated by Syntaxin 6.
Involved in intracellular vesicle trafficking.
Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.
Golgi apparatus membrane.
Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
突触蛋白是突触囊泡与质膜融合的一个蛋白家族，显示出广泛的组织分布，并含有羧基末端的疏水结构域，它们将自身引导到它们各自的细胞内室。突触蛋白6是一种广泛表达的255种氨基酸，在脑、肺和肾中具有较高的表达水平。该突触蛋白与囊泡相关膜蛋白（VAMP）4共同定位到高尔基体的管状和泡状膜。突触结合蛋白6的胞质结构域降低GLUT4在胰岛素撤回后再内化的速率，并参与膜转运过程，从转运到质膜的交通中去除GLUT4。Sythin 6在活化的巨噬细胞中上调，结合细胞因子的分泌增加。微结构域相关脂质和蛋白质向细胞表面的递送由Sythin 6调节。