国际站：AM580 (CD336)
CAS：102121-60-8
分子量：351.44
Formula：C22H25NO3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
产品活性：AM580 (CD336) (GMP) 是 GMP 级别的 AM580 (HY-10475)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。AM580 是一种选择性的 RARα 激动剂。
生物活性：AM580 (CD336) (GMP)是按照GMP指南生产的AM580 (HY-10475)。GMP小分子适合作为细胞治疗生产的辅助试剂。AM580是一种选择性RARα激动剂[1][2][3][4]。
体外：
AM580 (GMP) (0.05 μM)可诱导小鼠胚胎成纤维细胞(mef)在I期和II期培养基中转化为化学诱导多能干细胞(CiPSCs)[1]。
Am580 (gmp) (0-10 μm;4 d)诱导SH-SY5Y细胞发育为神经元样细胞[2]。
AM580 (GMP)对急性早幼粒细胞白血病细胞表现出强大的选择性细胞分化作用[3]。
Am580 (gmp) (2.5 μm;4 d)诱导髓系祖细胞发育成中性粒细胞[4]。
参考文献：
[1]. Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23(1):31-45.e7.
[2]. Cai A, et al. Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment. Neurochem Res. 2022
[3]. Gianní M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87(4):1520-31.
[4]. Brok-Volchanskaya VS, et al. Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA. Stem Cell Reports. 2019 Dec 10;13(6):1099-1110.