Anti-cAMP Mouse Monoclonal Antibody-抗体-抗体-生物在线
武汉纽斯特生物技术有限公司
Anti-cAMP Mouse Monoclonal Antibody

Anti-cAMP Mouse Monoclonal Antibody

商家询价

产品名称： Anti-cAMP Mouse Monoclonal Antibody

英文名称： Anti-cAMP Mouse Monoclonal Antibody

产品编号： 26002-1

产品价格： null

产品产地： 美国

品牌商标： NewEastbio

更新时间： null

使用范围： ELISA, WB, IHC

武汉纽斯特生物技术有限公司
  • 联系人 :
  • 地址 : 武汉市东湖新技术开发区光谷生物城B3-3栋2-3楼
  • 邮编 : 430074
  • 所在区域 : 湖北
  • 电话 : 186****7297 点击查看
  • 传真 : 点击查看
  • 邮箱 : neweast3@126.com
进入展台

cAMP [26002-1]
[30 µL]		  

Catalog Number:  26002-1
Gene Symbol:  
Description:   Anti-cAMP Mouse Monoclonal Antibody
Background:   cAMP is a ubiquitous second messenger mediating cellular responses to various exogenous and endogenous signaling molecules. cAMP regulates physiological processes by activating protein kinases, gating specific ion channels, modulating cellular cyclic nucleotide concentrations through phosphodiesterases, and activating Epac (exchange protein directly activated by cAMP). The conversion of ATP to cAMP is catalyzed by adenylyl cyclases (ACs). The major family of ACs in mammals is the transmembrane ACs which have nine isoforms and could be activated by G protein Gs and/or Ca2+/calmodulin. There is also one soluble AC which could be modulated by bicarbonate and/or Ca2+.
Immunogen:   cAMP
Applications:   ELISA, WB, IHC
Recommended Dilutions:   ELISA 1:1000-1:5000, WB 1:1000-1:2000
Host:   mouse
Format:   Liquid
Clonality:   Monoclonal
Isotype:   IgG
Purity:   Purified from ascites
Storage buffer:
Preservative:  no
Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:  
Storage Conditions:  Store at -20°C. Avoid freeze / thaw cycles
 
Typical Standard Curves  
    Sensitivity
 

Acetylated Version
Mean OD for Bo = 0.565 ± 0.007
Mean OD for Standard #6 = 0.500 ±0.006
Delta Optical Density (0-0.08 pmol/mL) = 0.065
2 SD's of the Zero Standard = 0.014
Sensitivity =(0.014/0.065)*0.08 pmol/mL=17 fmol/mL
Publications:
1.  Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1
    Pflugers Arch. 2012 Feb;463(2):257-68
2.  Antiarrhythmic effect of prolonged morphine exposure is accompanied by altered myocardial adenylyl cyclase signaling in rats
    Pharmacol Rep. 2012;64(2):351-9
3.  Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid beta(1-42)
    Neuropharmacology. 2013 Apr;67:272-83
4.  Subendocardial Increase in Reactive Oxygen Species Production Affects Regional Contractile Function in Ischemic Heart Failure
    Antioxid Redox Signal. 2013 Mar 20;18(9):1009-20
5.  Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1
    Pflugers Arch. 2012 Feb;463(2):257-68
6.  Structural basis of anthrax edema factor neutralization by a neutralizing antibody
    Biochemical and Biophysical Research Communications Volume 417, Issue 1, 6 January 2012, Pages 324–329
7.  Transgenic rescue of defective Cd36 enhances myocardial adenylyl cyclase signaling in spontaneously hypertensive rats
    Pflügers Archiv - European Journal of Physiology October 2013, Volume 465, Issue 10, pp 1477-1486
8.  Opposing HDAC4 nuclear fluxes due to phosphorylation by β adrenergic activated PKA or by activity or Epac activated CaMKII in skeletal muscle fibres
    The Journal of Physiology Volume 591, Issue 14, pages 3605–3623, July 2013
9.  Sex is a major determinant of neuronal dysfunction in Neurofibromatosis Type 1
    Annals of Neurology Volume 75, Issue 2, pages 309–316, February 2014
10.  cAMP–PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3–Orai1 complex
    Pflügers Archiv - European Journal of Physiology October 2014, Volume 466, Issue 10, pp 1921-1932
11.  Immunomodulating effects of casein-derived peptide QEPVL and QEPV on lymphocytes in vitro and in vivo
    Food Funct., 2014,5, 2061-2069
12.  Agonist-Dependent And -Independent Dopamine-1-Like Receptor Signalling Differently Regulates Downstream Effectors
    FEBS Journal Volume 281, Issue 21, pages 4792–4804, November 2014
13.  Alteration of vascular reactivity in heart failure: Role of phosphodiesterases type 3 and 4
    British Journal of Pharmacology Volume 171, Issue 23, pages 5361–5375, December 2014
14.  Ischemia/Reperfusion-Induced CHOP Expression Promotes Apoptosis and Impairs Renal Function Recovery: The Role of Acidosis and GPR4
    PLoS One. 2014 Oct 24;9(10):e110944
15.  Comparative study of somatostatin-human serum albumin fusion proteins and natural somatostatin on receptor binding, internalization and activation
    PLoS One. 2014 Feb 27;9(2):e89932