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Eriodictyol

CAS No. : 552-58-9

MCE 国际站：Eriodictyol

产品活性：Eriodictyol 是从中草药中得到的黄酮类，具有抗氧化、抗炎的功效。Eriodictyol 能够诱导 Nrf2 信号通路。Eriodictyol 还是一种流感依赖 RNA 的 RNA 聚合酶抑制剂，IC₅₀ 为 18 nM。

研究领域：NF-κB  |  Anti-infection  |  Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease

作用靶点：Keap1-Nrf2  |  Influenza Virus  |  DNA/RNA Synthesis  |  Endogenous Metabolite

In Vitro: Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ_25-35-induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons.

In Vivo: Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues.

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